for them, it was the best time,”says Krivosheyev. “Because you had nothing and all [of a] sudden the whole world was right in front of you. Like with a snap of somebody’s fingers.It was unbelievable.” But the gains of the Yeltsin 1990s also brought decay.There were multiple bank defaults, millions in average Russians’ savings lost, a gangster-style business culture, and the vaunted Red Army reduced to a punchline. Overwhelmed with the scope of the changes underway, Yeltsin told Russia’s regions to “take as much freedom as you need.”healthy livingSoon, wars for independence in Chechnyawould test the sustainability of the new cheers Russian Federation itself. Was Thanking You it a time of great democratic freedom?A top health websites time of gangster capitalism?A period of national decline? In reality, it was all of the above and then some.Personal experience dictated attitudes.In the post-Soviet space, there was no one singular story. But certainly it was a time for personal reinvention. Talk to anyone from that period, and they will regaleyou with stories of shifting professions, multiple political dalliances,fortunes won and, more often,lost. Indeed, it could seem as though the norms of daily life were suddenly rendered meaningless. Teenagers could suddenly earn more much, much more than the parents who raised them.Friends who grew up in those years recall the exhilaration and shame at bringing home paychecks far beyond their parents’ wildest dreams.
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Food and Drug Administration (FDA) that testing in humans may proceed for an investigational new drug for Alzheimer’s disease after more than 10 years of research by scientists at Vanderbilt University and Vanderbilt University Medical Center. It is relatively uncharted territory for an academic drug discovery group to take a molecule from the laboratory setting to the clinical trials stage. “The movement to the clinical phase of the research is the result of tireless colleagues reaching across disciplines in pursuit of the shared goal of hoping to someday improve the lives of individuals with Alzheimer’s disease and possibly other brain disorders, such as schizophrenia,” said Provost and Vice Chancellor for Academic Affairs Susan R. Wente, Ph.D. “This work exactly illustrates the critical role that basic science conducted in partnership with a world-class medical center can play in advancing knowledge in an attempt to fight a devastating disease.” For Alzheimer’s disease, the aim is for the investigational drug to target major pathologies of the disease and selectively activate a key receptor in the brain. The Vanderbilt researchers believe that the current standard of care for Alzheimer’s disease, cholinesterase inhibitors, has a different mechanism of action. They are hoping to establish through future clinical testing that the molecule is broadly effective across a number of cognitive and neuropsychiatric disorders, including schizophrenia. “This is the first instance I am aware of where an academic drug discovery group moved a molecule designed to hopefully treat a chronic brain disorder all the way from early discovery to human trials without there being, at some point along the way, a pharmaceutical partner,” said P. Jeffrey Conn, Ph.D., Lee E.
For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/vumc-ind122716.php
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